| 초록 |
Cell-based immunotherapies typically depend on ex vivo culture of a patient’s cells, and/or biomaterials that must be surgically implanted to program host immune cells. Here, we propose that high aspect ratio, mesoporous silica rods can be injected into the body via a needle, and spontaneously assembled to form macroporous structures that provide a 3D cellular microenvironment for host immune cells. Substantial numbers of DCs are recruited to the interparticle macropores of the injected scaffold. The DC recruitment and subsequent homing to lymph nodes can be modulated by sustained release of inflammatory signals and adjuvants, respectively. Moreover, injection of vaccine formulation enhances systemic TH1 and TH2 serum antibody and cytotoxic T cell levels. This suggests this injectable vaccine platform could be used to modulate host immune cells and provoke adaptive immune responses against various pathogens, and more broadly demonstrate their potential utility for cell therapies. |
