| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Amphiphilic antiviral delivery nanoplatform possesing cell-targeting phenylboronic acid functional groups for virus therapy |
| 초록 |
Influenza, one of the most contagious diseases, has caused seasonal epidemics and pandemics being a consistent concern for global health. Despite laudable advances in antiviral agents and drugs, the vast majority of them have shown limited efficacy due to non-specificity and low viability in physiological or endosomal environment, especially in the case of intracellular drug. A nano platform, consisting of phenylboronic acid (PBA) pendant group polymer which has sialic acid-targeting property, gained greater access to the intracellular space transporting antivirals within the host cell. Amphiphilic copolymers made of pPhe-b-mPEG-PBA formed polymersomes which encapsulated hydrophilic antiviral agents in the core and hydrophobic drugs in the exterior layer. Combination of antiviral drug delivery using amphiphilic nanocarrier and cell-targeting functional group gives a better chance to improve transfection and intracellular distribution efficiency of therapeutic substances. |
| 저자 |
천해진1, 김현욱1, 임종우1, 윤다연1, 김지혜1, 박근선1, 기지선1, 송대섭2, 함승주1
|
| 소속 |
1연세대, 2고려대 |
| 키워드 |
Phenylboronic acid; sialic acid; polymersome; PBA; antiviral; drug delivery
|
| E-Mail |
|
