| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.177 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Effect of Conformation of Glucosylated Polyethylenimine as Gene Carrier on Cell Recognition in vitro and in vivo |
| 초록 | Cancer is a complex acquired disease that affects millions of individuals each year. Underlying the pathogenesis of cancer are a variety of molecular genetic abnormalities which can be inherited or environmentally induced and result in unregulated cell proliferation. Conventional treatment strategies used to treat cancer such as surgery, chemotherapy, and radiation have been only partially successful and new treatment options are critically needed. Gene therapy is currently being explored experimentally as an alternative or addition to established treatment options for malignant melanoma, leukemia, glioma, and others. The aim of this therapy is the introduction of a gene or cells resulting in the indirect elimination or direct killing of tumor cells. One of the most common and profound phenotypes of highly malignant tumors, known for more than seven decades, is their ability to metabolize glucose at high rates. This is a characteristic of highly malignant animal and human tumors including those derived from brain, colon, liver, lung, pancreas, stomach, and retina. For each, a close correlation exists among the degree of differentiation, growth rate, and glucose metabolism, where the most poorly differentiated tumors exhibit the fastest growth and the highest glycolytic rate. Therefore, glucosylated polyethylenimine(PEI) was synthesized with varying substitution degree for tumor-targeting gene carrier and its potential was examined using lung cancerous cell line. Effect of conformation of glucosylated polyethylenimine as a gene carrier on cell recognition was checked. |
| 저자 | 박인규1, 국승은1, 조명행1, 김은미2, 정환정2, 김상헌3, T. Akaike3, 조종수1 |
| 소속 | 1서울대, 2원광대, 3동경공대 생체분자기능공학과 |
| 키워드 | Polyethylenimine; gene carrier; tumor targeting; carbohydrate conformation |
