| 초록 |
Reactive oxygen species (ROS) cause oxidative stress related to aging and cancer. Skin is frontal tissue that faces ultraviolet light directly, so antioxidant treatment is essential. Flavonoids are an effective antioxidant, however, the stability and skin penetration aren’t enough to protect skin effectively. In this regard, we fabricated liposomal formulation to enhance stability, antioxidation and skin penetration. A non-ionic surfactant was used to stabilize liposome and enhance skin penetration. The formulation was optimized with various lipids, preparation methods and evaluated by live-cell ROS detection assay, Franz diffusion cell. The remote loading method with fully-saturated phospholipids showed the highest loading contents of flavonoid, stability of formulation and antioxidation activity with high skin penetration. The cytotoxicity of liposome was negligible in vitro test. Therefore, new formulation of flavonoid represents a promising platform for pharmaco-cosmetic industry. |
