| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.269 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Antitumor efficacy of temperature-sensitive liposomes modified with thermosensitive polymer by hyperthermia |
| 초록 | The temperature-sensitive liposomes (TS-liposomes) have been developed in the field of the chemotherapy to increase drug release at tumor site. In this study, we used polyethyleneglycol coated TS-liposomes (PETS-lipoosmes) modified with a thermosensitive polymer, poly(N-isopropylacrylamide-co-acrylamide) (PNIPAM-AAM) in combination with hyperthermia to treat a mouse tumor, B16F10 melanoma. In tumor treatment, intravenous injection of the modified PETS-liposomes with PNIPAM-AAM in combined with hyperthermia suppressed the tumor growth and generated smallest tumor in volume (Fig. 1). Thus, our results demonstrate the potential of the modified PETS-liposomes in tumor treatment and are valuable in designing thermosensitive polymer modified PETS-liposomes for use as drug delivery systems on the specific tumor targeting by external hyperthermia. Fig. 1. Antitumor efficacy of PETS-liposomes in combined with hyperthermia. |
| 저자 | 한희동1, 신병철1, 최민수1, 황태원1, 최호석2 |
| 소속 | 1한국화학(연), 2충남대 |
| 키워드 | temperature-sensitive liposomes; thermosensitive polymer; hyperthermia |
