| 초록 |
The near-infrared (NIR) window refers to the range of wavelengths of 700~1300 nm in which biological tissues are transparent. It can be possible to employ light at these wavelengths for the monitoring and triggering of biological events in vitro and vivo. Photoacoustic tomography (PAT) takes advantage of NIR absorbing materials for transducing light into the non-radiative signal. Another one is a fluorescence imaging which provides high resolution and sensitivity. Here, we report an exfoliated MoS2 as an intrinsic multimodal contrast agent for both imaging techniques. MoS2 is a mixed phase 2-dimensional graphene analogue which has unique light absorbing property. To enhance stability of MoS2, we conjugated thiol functionalized hyaluronate (HA) to MoS2 via the thiol chemistry. After in vitro characterization of photoluminescence and photothermal effect, HA-eMoS2 conjugate was successfully applied for both cancer imaging and therapy. |
