| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Nanodiamond Clusters Decorated with Folic Acid for Photothermal Tumor Therapy |
| 초록 |
We designed ND nanoclusters decorated with folic acid (FA) as a targeting moiety and utilized the photothermal effect of NDs upon NIR laser irradiation for tumor therapy. To evaluate the photothermal property of ND nanoclusters with various ND concentrations, samples were prepared and then exposed to NIR laser ( λ = 808 nm) for 5 min. in vivo tumor specificity and therapeutic efficacy also examined by injecting ND and FA-ND nanoclusters into tumor-bearing nude mice through a tail vein. FA-ND nanoclusters exhibited specific cellular uptake to KB cells. The viability of KB cells treated with FA-ND cluster was reduced to 5.4% (94.6% of ablation ratio) along the light of NIR laser. An in vivo studies revealed that FA-ND nanoclusters selectively accumulated in tumor tissue and effectively reduced tumor volume from 36.1 ± 5.2 mm3 to 21.4 ± 4.9 mm3 by the NIR laser-exposed. We demonstrated the superior performance of FA-ND nanoclusters for selective photothermal tumor therapy. |
| 저자 |
최성욱 |
| 소속 |
가톨릭대 |
| 키워드 |
nanodiamond; drug delivery; tumor therapy;
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| E-Mail |
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