| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Hydrotropic Oligomer-Conjugated Glycol Chitosan as a Carrier of Paxclitaxel: Synthesis, Characterization, and In Vivo Biodistribution |
| 초록 |
As a potential drug carrier of paclitaxel, hydrotropic oligomer-glycol chitosan (HO-GC) was synthesized by chemical conjugation of the N,N-diethylnicotinamide-based oligomer, uniquely designed for enhancing the aqueous solubility of paclitaxel, to the backbone of glycol chitosan. Owing to its amphiphilicity, the conjugate formed self-assembled nanoparticles. They could encapsulate a high quantity (20 wt%) of paclitaxel (PTX) with a maximum drug loading efficiency of 97%, due to the presence of hydrotropic inner cores. From the cytotoxicity test, it was confirmed that HO-GC-PTX nanoparticles showed lower cytotoxicity than free PTX formulation in Cremophor EL/ethanol mixture. The optical imaging results indicated that near-infrared fluorescence dye (Cy5.5)-labeled HO-GC-PTX showed an excellent tumor specificity in SCC7 tumor-bearing mice, due to the enhanced permeation and retention effect. Overall, HO-GC-PTX nanoparticles might be a promising carrier for PTX delivery in cancer therapy. |
| 저자 |
민경현1, 김광명2, 박재형1, 권익찬2, 박기남3, 정서영1
|
| 소속 |
1경희대, 2한국과학기술(연), 3Purdue Univ. |
| 키워드 |
hydrotropic oligomer; glycol chitosan; self-assembled nanoparticles; paclitaxel; cancer therapy
|
| E-Mail |
|
