| 초록 |
We studied about the synthetic method of PEGylated gold nanorods (PGNRs) and applications for photothermal therapy of epithelial cancer using near-infrared (NIR) light. Because GNRs are desirable to use photothermal agents that are active in NIR region and biocompatible. GNRs are typically prepared in the presence of hexadecyl trimethylammonium bromide (CTAB). The elimination of CTAB on GNRs is necessary due to its cytotoxicity and membrane-compromising properties. Therefore, the surface of GNRs was modified with polyethylene glycol (PEG) instead of CTAB and excess CTAB was removed by dialysis. Optical properties of PGNRs were analyzed using ultraviolet-visible spectroscopy. Size and morphology were evaluated by dynamic light scattering and transmission electron microscopy, respectively. In vitro cytotoxicity of PGNRs was assessed by MTT assay. Furthermore, we presented the photothermal destruction of cancer cells of in vivo tumor model using PGNRs and NIR light. |
