| 초록 |
Recently, surface modification using poly(ethylene glycol) (surface PEGylation) is of interest, because it prevents the non-specific adsorption of biomolecules which can interfere with desired functions of biomedical devices like implant. The surface PEGylation have been investigated by various approaches, such as grafting of functional polymers, adsorption of polyelectrolyte. On the other hand, the introduction of native chemical ligation techniques to join unprotected peptides next to a cysteine residue has greatly facilitated the synthesis of proteins of moderate size. Moreover, native chemical ligation chemistry have successfully been applied to various organic and bio-organic reactions. However, there are no reports for applying native chemical ligation to surface chemistry. Herein, we introduce a method for surface PEGylation of titanium substrate by phosphonic acid SAM formation on the substrate, followed by native chemical ligation of PEG. |
