| 학회 |
한국고분자학회 |
| 학술대회 |
2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 |
30권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Paclitaxel Controlled Release from Biodegradable Thermosensitive Poly(organophosphazene) Gels |
| 초록 |
We have synthesized biodegaradable thermosensitive poly(organophosphazene) gels bearing α-amino-ω-methoxy-poly(ethylene glycol), L-isoleucine ethyl ester and glycine lactate ethyl ester as side groups. Paclitaxel was loaded via physical mixing into the poly(organophosphazene) solution. The paclitaxel loaded poly(organophosphazene) solution showed the gelation at body temperature. The solubility of paclitaxel in poly(organophosphazene) solution was increased by more than 14,000-fold without any emulsifiers compared with that in PBS (pH7.4). The release behavior of paclitaxel loaded in the hydrogel was significantly sustained for 30 days. We found that the release behaviors of paclitaxel could be controlled by modulation of gel properties. |
| 저자 |
허정윤1, 이선미1, 안철희2, 송수창1
|
| 소속 |
1한국과학기술(연), 2서울대 |
| 키워드 |
poly(organophosphazene); paclitaxel
|
| E-Mail |
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