| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
Antibacterial Activity of Silver Containing Biodegradable Poly(vinyl alcohol)-block-Poly(L-lactide) Copolymer Micelles in Water |
| 초록 |
We synthesized uniform silver nanoparticles (AgNPs) with less than 10 nm in diameter via automatic reduction from AgNO3 without using any toxic reducing agent by utilizing well-defined biodegradable and biocompatible poly(vinyl alcohol)-block-poly(L-lactide) copolymer (PLLA-b-PVA) micelles in aqueous solution. The PLLA-b-PVA was synthesized by the combination of reversible addition-fragmentation chain transfer, ring opening polymerization and click chemistry. Synthesized AgNPs containing block copolymer micelles (PVA-b-PLLA@Ag) were very stable without showing any agglomeration. They showed excellent antibacterial activity against pathogenic Gram-positive and Gram-negative bacteria with prominent minimum inhibitory concentrations (MICs) value, because of the effective release of AgNPs from the micelles. Also, they exhibited low cytotoxicity against normal human embryonic kidney cell. |
| 저자 |
Avnish Kumar Mishra, 김진곤
|
| 소속 |
POSTECH |
| 키워드 |
antibacteria; silver nanoparticle; poly(vinyl alcohol); poly(L-lactide)
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| E-Mail |
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