| 초록 |
In this study, to improve both the biocompatibility and mechanical properties of cyanoacrylate, allyl 2-cyanocarylate was pre-polymerized and mixed with poly(L-lactide-co-ε-caprolactone)(PLCL, 50:50) as biodegradable elastomer and mixed with hydroxyapatite(HA) as multifunctional bio-glue for variety body application. Hybridized allyl 2-cyanoacrylate(Hybridized Cy) was mixed with pre-polymerization allyl 2-cynaocarylate and PLCL. For the evaluation of various properties of hybridized Cy/HA bio-glue mixtures, bond strength, surface analysis(SEM, XRD), cell viability, and biocompatibility were confirmed. Especially, optimal condition for hybridized Cy/HA bio-glue was determined as 1.2 wt% HA mixture ratio through bond strength. Surface morphology has smooth form to increase HA mixture ratio. Cell viability increased with optimal ration of hybridized Cy/HA. These results indicate that hybridized Cy/HA bio-glue can be used widely as advanced adhesive in various fields. |
