| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Photo-responsive drug delivery platform using gold nanorod contained nanofiber. |
| 초록 |
External stimuli has received considerable attention where the drug release profile can be controlled to achieve an on-demand supply of the drug at a desired dose. The improved absorbance and scattering properties of gold nanorods makes them potentially useful for drug delivery. We designed a platform in which gold nanorods were introduced in the matrix of the nanofiber that helped for drug release by providing heat. Electrospun nanofiber has large surface area-to-volume ratio which is used to effectively deliver large quantities of drug. The advantage of this method is that a wide variety of low solubility drugs can be loaded into the fibers to improve their bioavailability or to attain controlled release due to shrinkage of poly (N-isopropylacrylamide) (PNIPAM). The fabrication of nanofiber is done by electrospinning of PNIPAM cross-linking with OpePOSS including gold nanorods. Furthermore, it is possible to introduce sequential release of multiple drugs. |
| 저자 |
발진더 싱1, 박명환2, 조찬현2
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| 소속 |
1Sahmyook Univ., 2삼육대 |
| 키워드 |
Electrospinning; Nanofiver; PNIPAM; Gold-Nanorods; Near-infrared Radiation.
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| E-Mail |
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