| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Advanced Transarterial Chemoembolization using Magnetic Janus Microparticles with Anti-Angiogenetic Drugs for Liver Cancer |
| 초록 |
The majority of the causes of liver cancer is due to HCC (hepatocellular carcinoma), which is difficult to diagnose early. Transarterial chemoembolization (TACE) is one of methods for treatment of liver cancer, which induce necrosis of cells by injecting catheter into the hepatic artery and sending microparticles that can block blood vessels connected with cancer cells. Although TACE is very effective method for unrespectable HCC with prolong survival, recurrence of tumor by angiogenesis is inevitable. Here, we prepare polymeric Janus microparticles with two compartments, which one is polycaprolactone-rich phase and the other is poly(lactide-co-glycolic acid)-rich phase. To apply magnetic anisotropy and the synergistic effects, iron oxide nanoparticles and anti-angiogenetic drugs are added into microparticles. The motions-induced by the magnetic field enables the active drug-release and results in the use of the microparticles for the promising therapeutic tools to cancer treatment. |
| 저자 |
민남기1, 조수정2, 박우람3, 김신현1, 김동현2
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| 소속 |
1KAIST, 2Northwestern Univ., 3CHA Univ. |
| 키워드 |
Microparticles; drug delivery system; Liver cancer; magnetic anisotropy
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| E-Mail |
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