| 학회 | 한국공업화학회 |
| 학술대회 | 2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 | 19권 2호 |
| 발표분야 | (생체재료) 나노기술기반 헬스케어소재 |
| 제목 | Near-Infrared Fluorophores for Imaging, Targeting and Therapy |
| 초록 | To be clinically viable, the ideal NIR fluorophore requires certain optical properties, including excitation and emission ≈800 nm, and a high extinction coefficient and quantum yield in serum. To date, every NIR fluorophore described in the literature suffers from two fundamental flaws: 1) hepatic clearance, which results in NIR fluorescence signal throughout the GI tract that persists for hours, and/or 2) non-specific background uptake in normal tissues, which typically persists for hours and results in a low signal-to-background ratio (SBR). The goal of this work is to develop a new class of ideal NIR fluorophores that can be injected into the bloodstream. These fluorophores would “stick” to tumors and other diseased tissue, but not to normal tissue. Currently, we are developing on the synthesis of optimized NIR fluorophores for in vivo and surgical imaging, on validating their use as targeted diagnostic agents for various diseases including cancer. Completion of these aims will lay the foundation for future clinical testing during image-guided surgery. |
| 저자 | 현훈 |
| 소속 | 전남대 |
| 키워드 | Near-infrared imaging; Near-infrared fluorescences; Targeted Fluorophores |
