| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_무기재료 |
| 제목 |
Facile synthesis and direct characterization of surface-charge-controlled magnetic iron oxide nanoparticles and their role in gene transfection in human leukemic T cell |
| 초록 |
Appropriate surface designs and precise characterizations of nanoparticles (NPs) are important for biomedical applications of nanomaterials. We report a facile synthetic approach to the preparation of Fe3O4 NPs with different surface charges through exchange with polymeric ligands. An accurate analysis method for characterization of the surface-modified Fe3O4 NPs using a combination of the ToF-SIMS and FT-IR techniques is demonstrated. A comparison of the spatial distribution of the ligand and core particles with ToF-SIMS and FT-IR verified the successful modification and purification. In addition, the surface was shown to play an important role in interactions with live cells in terms of cytotoxicity, cellular uptake, and even gene transfection. |
| 저자 |
김현홍1, 김성환1, 나희경2, 손진경2, 이태걸2, 박종남1
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| 소속 |
1UNIST, 2KRISS |
| 키워드 |
Surface modification; Characterization of surface coated material; Chemical information of nanoparticle surface; Transfection of suspension cell
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| E-Mail |
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