| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Genetically Engineered Fusion Proteins for Anti-angiogenesis |
| 초록 |
Genetically engineered fusion proteins for anti-angiogenesis have been of growing interest to treat uncontrolled neovascularization. We are interested in elastin-based polypeptide (EBPs) as thermo-responsive biopolymers with reversible phase transition, and their fusions with functional peptides to control biological phenomena at cell level. Herein, we report stimuli responsive EBP fusion proteins with the anti-angiogenic peptides (APs) in the form of soluble monomers, which can bind to the cell receptors and trigger cellular signaling for anti-angiogenesis. These fusion proteins with four different EBP block lengths showed lower critical solution temperature (LCST) behavior, and the LCSTs were finely controlled by the EBP block length. The anti-angiogenesis function was studied in vitro by human umbilical vein endothelial cells tubing assay depending on EBP block lengths. Potentially, these fusion proteins with the AP moieties would be useful as biodrugs to treat neovascularization. |
| 저자 |
강민정1, 이재상2, Aamna Basheer1, 임동우2
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| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ. |
| 키워드 |
Genetic engineering; Fusion proteins; Stimuli responsiveness; Anti-angiogenesis; Nanomedicine
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| E-Mail |
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