| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.18 |
| 발표분야 | 특별 심포지엄 |
| 제목 | Nanostructures in Polymer-Lipid Systems |
| 초록 | Lipids, main components of biological membrane, are defined as biomolecules that are sparingly soluble in water and freely soluble in organic solvents. Due to their amphiphilic properties, lipids form a variety of lyotropic liquid crystalline phases in the presence of water. Many techniques have been developed to formulate micro- and nano-systems by utilizing the interaction between polymers and lipids. This talk will serve as an introduction to such microstructures formed by polymer-lipid systems. Nano-porous hydrogel-type polymers have been prepared inside the lipid cubic phase with three-dimensional symmetry. The interconnected open pores have a diameter ranging 2 ~ 8 nm. The lipid cubic particles also known as Cubosomes®, stabilized by triblock copolymers, are emerging as a novel drug delivery system. Due to the versatility to encapsulate protein and insoluble drugs, Cubosomes® are recognized as efficient oral drug delivery systems. New classes of lipids, polymerizable and polymeric lipids, have been synthesized to increase the stability of lipid microsystems. Polymerizable lipids form microtubules that have a diameter of approximately 500 nm and a length ranging up to a few centimeters. Tubules are hollow inside and open-ended on both ends with walls formed by one or more lipid bilayers. An interesting feature of the microtubule is that it can be coated with metal. Metal coated tubules can be used as a dielectric materials and nanotubes. Many lipid microstructures can be stabilized by the aid of polymeric lipids or amphiphilic polymers. For instance, liposomes and lipid emulsions can be stabilized by adding Tween 80 or Pluronics. Polymers mix with lipids in some occasions to change the bulk lipid structures. Polymer induces a lamellar-to-hexagonal phase transition when DNA, an anionic biopolymer, is mixed with cationic liposomes. Understanding the mechanism behind the formation of and physical properties of the hexagonal phase would be essential to design lipid based gene delivery systems. |
| 저자 | 정혜선 |
| 소속 | 한국과학기술(연) |
| 키워드 | lipid; polymer; hydrogel; polymerizable lipid; nanoporous material |
