| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.247 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Study on the feasibility of MePEG/PLGA implantable matrix as a drug carrier for the treatment of otitis media |
| 초록 | For the desirable delivery of hydrophobic drugs, dexamethasone as a model drug, methoxy polyethylene glycol (MePEG)/poly (D,L-lactide-co-glycolide) (PLGA) amphiphilic copolymers were synthesized by ring opening polymerization. The synthesized MePEG/PLGA copolymers were grinded and mixed with fine dexamethasone for the preparation of implantable wafers by means of conventional direct compression method for the treatment of otitis media. In order to compare the drug release patterns, the MePEG/PLGA wafers and conventional PLGA wafers were incubated in phosphate buffered saline (PBS) at 37℃. From the result of in vitro release tests, the MePEG/PLGA wafers showed more desirable drug release based on the short degradation duration of MePEG/PLGA matrix comparing with conventional PLGA wafers. Further investigation is being carried out to identify the effect of dexamethason-loaded MePEG/PLGA wafers in in vivo. Acknowledgment : This work was supported by KMOHW and KOSEF (R01-2001-00431) |
| 저자 | 김종민1, 유제영1, 서광수1, 정제교2, 김문석3, 조선행3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2삼천당제약 중앙(연), 3한국화학(연) |
| 키워드 | MePEG/PLGA matrix; Implantable |
