| 초록 |
L-Ascorbic acid (AA) is one of the interesting and well-known acids in nature which can be used in cosmetic, pharmaceutical, and food industry due to its bioactivity and anti-oxidation property. But the bioavailability of AA decreases with time because it is spontaneously oxidized in the presence of oxygen. Cyclodextrin (CD) which has hydrophobic inside and hydrophilic outside, can encapsulate various organic/inorganic molecules to form the inclusion complex with hydrophobic compounds. Thus they can enhance the solubility and chemical stability of such compounds in aqueous solution and finally increase the bioavailability. This study aimed to prepare the novel skin whitening agent including CD, which has better properties in skin permeation, whitening efficiency and duration time than the existing product. AA was covalently bonded to β-CD using succinic anhydride (SAH). β-CD-SAH-Vitamin C was synthesized by using EDC as a catalyst and characterized through FT-IR, 1H NMR, 13C NMR. |
