| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생물공학 |
| 제목 |
Profiling of N-Glycan based on Mass-spectrometry for pancreatic cancer metastasis tracking |
| 초록 |
The abnormalities in glycosylation profile manifested among cancer cells has been recognized for its biomarkers towards assessing tumor progression. This study is the first diagnostic biomarker profiling on three types of pancreatic cancer cells (Capan-1, Panc-1 and MIA PaCa-2) from different sites of pancreatic tumor. 41 N-glycans present on the surface of normal and cancerous pancreatic cells were idenfied and relatively quantified using MALDI-TOF MS and MALDI-QIT-TOF MS/MS analysis coupled with solid-phase permethylation. These findings indicate that they can be used to differentiate normal and pancreatic cancer cells by specific N-glycosylation profile changes, as well as provide more information about their location and metastatic potential. |
| 저자 |
김성민1, 송원석2, 조성현1, 이재승1, 전효진1, 김윤곤1
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| 소속 |
1숭실대, 2서울대 |
| 키워드 |
N-glycan; MALDI-TOF MS; Pancreatic cell
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| E-Mail |
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