| 초록 |
Stimuli responsive injectable hydrogel have potentials as bone repairing due to their ability to form three-dimensional networks under mild conditions, to be introduced into body in a minimally invasive manner. Also, alginate is broadly studied because of not only similar property above but also ease of chemical modification with adhesion ligand. Recently, our group proposed temperature sensitive hydrogels as carriers for Bone Morphogenetic Protein 2 (BMP-2). The hybrid polymer Alg-PCLA was comprised of alginate and poly(ε-caprolactone-co-lactide). Alg-PCLA was blended with poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) to form hybrid hydrogel. Alginate is modified with phosphate group which can induce hydroxyapatite and increase mineralization property. Hybrid hydrogel exhibited sustained BMP-2 release and hydroxyapatite was well induced in vitro. Thus, we can expect alginate based injectable hydrogel has great potential for bone repair. |
