| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Evaluation of Pegylated-prodrug nanoparticle for Enhanced solubilization and Anticancer effect of Chlorambucil |
| 초록 |
Chlorambucil (CLB), which was used as a leukemia curing agent, proved its anti-cancer effect in a recent study. CLB has the disadvantage such as high toxicity, MDR effect, and poor solubility in water. To overcome a these obstacle, we synthesized pegylated-CLB prodrug nanoparticles with coupling agent. Its chemical structure was confirmed by 1H-NMR and UV-vis spectrophotometer. To demonstrate a solubilization of CLB against water, solubility test was conducted according to various concentration of prodrug, which was measured by using UV-vis spectrophotometer. Its particle size and morphology were analyzed by DLS and TEM. Beside, anticancer effect was confirmed by using MTT assay. Cellular uptake of that was analyzed by using fluorescence microscopy and flow cytometry. (NRF-2016H1D5A1910499). |
| 저자 |
정경원, 정은희, 남충현, 안준혁, 홍웅길, 나재운
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| 소속 |
순천대 |
| 키워드 |
Chlorambucil; Pegylated-chlorambucil; Prodrug; Anticancer effect
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| E-Mail |
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