| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Dexamethasone loaded PLGA Scaffolds for Chondrogenic Differentiation of Bone marrow mesenchymal stem cells |
| 초록 |
Bone marrow mesenchymal stem cells (BMSCs) are capable of differentiating into connective tissue-forming cell lineages. Known as an alternataive cell source to chondrocytes, many studies have utilized them for in vitro cartilage formation under an appropriate 3D environment, along with the use of growth factors and dexamethasone (DEX). These would stimulate cartilaginous matrix prodution. In particular, TGF-β1 is a multifunctional protein that promotes the proliferation of BMSCs and enhances the chondrogenic differentiation in vitro. And dexamethasone has been shown to induce chondrogenic differentiation in Bone marrow mesenchymal stem cell. Therefore growth factors and a DEX loaded porous scaffold might be a plausible tactics in improving cartilage-forming efficacy of BMSC. In the present work, we hypothesized that this novel DEX loaded scaffolds may be a suitable platform for the induction of chondrogenic differentiation of BMSC. |
| 저자 |
조경진1, 박귀덕1, 김익환2, 안광덕1, 한동근1
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| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
Tissue engineering; PLGA scaffolds; Dexamethasone; Transforming growth factor-beta; Bone marrow mesenchymal stem cells
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| E-Mail |
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