| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Preparation and Characterization of Doxorubicin-loaded Redox-responsive chitosan nanoparticle as carrier for drug delivery |
| 초록 |
A lot of researchers have been designed to carriers composed of hydrophilic and hydrophobic substance in order to drug delivery in cancer cell. They had a problem that was led to sustained drug release in cancer cell, which induced to side effect and inefficient therapy. we used to lipoic acid (LA) and it was introduced to back bone of water soluble chitosan (WSC) by coupling agent. Chemical structure of LA-grafted water soluble chitosan (LWSC) was confirmed by 1H-NMR and FT-IR. Its critical aggregation concentration (CAC) was analyzed by fluorophotometer. Doxorubicin (DOX)-loaded LWSC (DLWSC) nanoparticles were prepared by dialysis method. To demonstrate redox-responsive effect of DLWSC, drug release behavior was accomplished in presence GSH. Cytotoxicity and anticancer activity conducted by using MTT assay. These results suggest that redox-responsive DLWSC is a superb anticancer agent for cancer therapy. (NRF-2016H1D5A1910499). |
| 저자 |
안준혁, 홍웅길, 정경원, 나재운
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| 소속 |
순천대 |
| 키워드 |
Water soluble chitosan; Lipoic acid; Doxorubicin; Redox-responsive
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| E-Mail |
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