| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
콜로이드·계면화학_포스터 |
| 제목 |
Tuning the stiffness of dermal fibroblast-encapsulating collagen gel for examining cellular functions |
| 초록 |
In this study, cross-linked collagen gels were successfully prepared with varying of elastic modulus from 0.70 to 17.7 kPa using a chemical cross-linker. Then, human dermal fibroblasts were encapsulated into the porous pores introduced into the gels, and cell growth and behavior were examined by gel’s mechanical properties. Specifically, increasing elastic modulus of the gel led to decreases in procollagen synthesized. In addition, there could be optimum elastic modulus for procollagen production, when the gels were treated with adenosine. However, interestingly, this study discovered that the procollagen production level was not influenced by the elastic modulus of the gel for GHK-Cu peptide. In conclusion, these results would be highly useful for designing reconstructive skins with varying of elastic modulus to examine functional materials in cosmetics. |
| 저자 |
신성규1, 변진아2, 한사라1, 조성우1, 임준우1, 정재현1
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| 소속 |
1숭실대, 2로랜플 |
| 키워드 |
Collagen gel; functional peptide; pro-collagen; Elastic modulus
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| E-Mail |
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