| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Evaluation of Small Intestinal Submucosa Coated with Poly(vinyl alcohol) as a wound dressing |
| 초록 | Small intestinal submucosa(SIS) consists of collagen and glycosaminoglycan and has some growth factors which can stimulate cell activity. Also, PVA is generally used in a field of wound dressing as hydrigel which is easy to remove from wounds. In this study, native SIS sheets were coated with PVA so that sheets improve wound healing and are easy to remove from wounds. Native SIS sheets were coated with PVA by immersing them into PVA solution of 2, 4, 10 wt% and then lyophilized. The surface morphology of the prepared SIS sheets was observed using SEM, and the mechanical properties were examined through tensile test. Also, enzymatic degradation, water uptake, and in-vitro test were characterized. To investigate the effects of prepared sheets on wounds, we made 3x3 cm2 full-thickness wound on the dorsal site of SD rats, measured peel strength and analyzed the wound healing histologically. The degradation ratio of the SIS sheets coated with PVA(PVA-SIS sheets) was decreased compare to native SIS. Water uptake ability was improved at PVA of 2, 4 wt%, and the degree of fibroblast attachment was lower than the native SIS sheets. PVA coated SIS sheets applied to injured area did not make the second damage when removed, and histological examination showed that those sheets enhanced wound healing and epithelialization of wounds. This study suggests that the PVA coated SIS sheets could be useful for the applications of wound dressing and biodegradable injectable materials. Fig 1. Fibroblast attachment of PVA-SIS sheets made on pore-foil or silicon mold with different concentration of PVA Acknowledgement : This work was supported by Korea Ministry of Commerce, Industry and Energy (N11-A08-1402-05-1-3) |
| 저자 | 이민숙1, 홍금덕1, 송인범2, 강길선1, 김문석2, 이혜경3, 이해방2 |
| 소속 | 1전북대, 2한국화학(연), 3대전성모병원 병리학과 |
| 키워드 | wound dressing; small intestinal submucosa(SIS); poly(vinyl alcohol); wound healing |
