| 초록 |
Furfuryl hyaluronic acid derivative (F-HA) was prepared to reduce adhesion of inter-tissue after surgical operation. Hyaluronic acid has biocompatibility, wound-healing effect, and biodegradable properties. In this study, We expect that F-HA could prevent adhesion because F-HA could make physical separation by coating the surgical site. Immobilized ibuprofen as anti-inflammatory drug slowly released and reduced inflammatory response and adhesion. Structure of prepared F-HA was analyzed using 1H-NMR. Also, for medical application, biocompatibility of F-HA was evaluated by WST assay. And, formation of physical barrier using F-HA was confirmed through cell penetration test. From these results, F-HA could be developed as biocompatible anti-adhesion. |
