| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
고분자가공/복합재료 |
| 제목 |
Optically switchable nanofiber membrane for on-demand drug delivery |
| 초록 |
Externally stimuli responsive on-demand drug delivery system could release drugs at the ideal time and ideal dose for a specific disease in a patient without an additional surgery. We have developed the versatile membrane using the thermo responsive poly(N-isopropylacrylamide) (PNIPAM) containing of gold nanorods(GNRs) by an electrospinning process. This light-responsive membrane generates localized heat around the GNRs in the fiber upon NIR irradiation. The increased heat of the membrane causes shrinkage of PNIPAM fiber, accelerating the release rate of drugs. The surface morphology of fabricated membrane was analyzed by scanning electron microscopy (SEM) and the released quantity of drugs was measured by fluorescence spectroscopy. We expect that this novel drug delivery system will improve a therapeutic efficacy and patients comfort and alleviate side effects. |
| 저자 |
조민철, 선동민, 박명환
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| 소속 |
삼육대 |
| 키워드 |
PNIPAM; electrospinning; drug delivery
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| E-Mail |
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