| 학회 |
한국공업화학회 |
| 학술대회 |
2008년 봄 (05/09 ~ 05/10, 한양대학교(안산)) |
| 권호 |
12권 1호 |
| 발표분야 |
정밀화학 |
| 제목 |
Synthesis and Evaluation of Radiolabeled Iodine Carbocyclic Nucleoside Analogue,cis-1-[4-(Hydroxymethyl)- 2-cyclopenten-1-yl]-5-[124I]iodouracil |
| 초록 |
In our pursuit to find an appropriate reporter probe for Herpes Simplex Virus Type-1 thymidine kinase (HSV1-tk), a carbocyclic nucleoside analogue, cis-1-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-5-[124I]iodouracil has been efficiently synthesized. Biological data reveal that the analogue is stable in vitro, less toxic than Ganciclovir (GCV), and selective to HSV1-tk expressed cells based on micro Positron Emission Tomography (microPET) image analyses. Thus, this new carbocyclic nucleoside, referred in this presentation as carbocyclic 2’,3’-didehydro-2’,3’-dideoxy-5-iodouridine (carbocyclic d4IU) is a potential imaging probe for HSV1-tk. |
| 저자 |
이학준1, 안현석1, Kathlia De Castro1, 최태현2, 안광일2, 이교철2
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| 소속 |
1한양대, 2원자력병원(연) |
| 키워드 |
HSV1-tk; carbocyclic nucleoside; radiolabeling; microPET
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| E-Mail |
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