| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and Release Behavior of Raloxifene HCl-loaded PLGA Microspheres |
| 초록 |
Abstract: Raloxifene HCl is a selective estrogen recepter modulator(SERM) and is currently being used for prevention of osteoporosis in postmenopausal women. We prepared raloxifene HCl loaded double-layered PLGA microspheres using O/O/W double emulsion solvent evaporation method. The raloxifene HCl loaded double-layered PLGA microsphere was characterized on the surface, and the cross-section morphology by SEM. In vitro release behavior of raloxifene HCl was analyzed by HPLC over 4 weeks. Double-layered PLGA microspheres showed smooth surface and obvious difference core and outer-shell by SEM observation. The influences of preparation parameters, such as molecular weight of PLGA and initial drug loading ratio, have been observed in the release behavior of raloxifene HCl. These results showed that the release behaviors can be effectively controlled by the preparation parameters. This research was supported by WCU(R31-20029). |
| 저자 |
김세호, 박종학, 엄신, 김용기, 박현진, 이영현, 유동혁, 김수진, 유일수, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
raloxifene HCl; O/O/W; PLGA; HPLC; Microspheres
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| E-Mail |
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