| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Biocompatible Polymer Coated Superparamagnetic Iron Oxide Nanoparticles for NIRF/MRI Multi Modal Imaging |
| 초록 |
During the past decades, various nanostructures have been exploited and successfully employed as a molecular imaging modality for disease detection. Especially, iron oxide based superparamagnetic nanoparticles (SPIONs) are one of the well-known candidates for magnetic resonance imaging and extensive research has been carried out on the investigation of disease. However, single imaging modality has limitations to allow overall structural, functional, and molecular information. Therefore, numerous nanostructures have been developed for multi modal imaging. In this study, we prepared biocompatible multi functional SPIONs to combine magnetic resonance imaging and near-infrared fluorescence (NIRF) imaging for cancer diagnosis using simple coating and coupling methods. Chemically modified biocompatible polymer for enhanced adhesive ability to nanoparticles was used as a biocompatible stabilizer for SPIONs and NIRF organic dyes were conjugated to polymer coating layer for optical imaging. |
| 저자 |
차의준1, 선인철2, 김광명2, 권익찬2, 안철희1
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| 소속 |
1서울대, 2한국과학기술(연) |
| 키워드 |
MRI; iron oxide; nanoparticles; NIRF; imaging; cancer; dual imaging
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| E-Mail |
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