| 초록 |
Nanobiophotonics is a fusion technology, merged at the interface of biomedical research, photonics, nanotechnology, and materials science. Properly designed nanomaterials can offer opportunities to create light-based modalities for next-generation therapies, by enabling early detection and selective treatment of diseases. For photoactivation of therapeutic agents, two-photon excitation with near-infrared light has advantages, including greater tissue penetration, better spatial resolution, and less phototoxicity, etc. In this presentation, we report a novel approach toward highly two-photon active nanoprobes, which utilizes cell-permeable organically modified silica nanoparticles encapsulating specially designed ‘molecular aggregates’ with aggregation-enhanced two-photon fluorescence. In vitro demonstrations with tumor cells, including fluorescence imaging-highlighting and photodynamic therapy, will be presented as promising two-photon nanobiophotonic applications. |
