| 초록 |
A polymeric nanogel with tumor targeting properties and a controllable phototoxicity was designed utilizing polysaccharide/photosensitizer conjugate. Polysaccharide (PS) was conjugated with different amounts of pheophorbide a (Pba), resulting in the formulation of self organizing nanogels in aqueous solutions. The nanogels observed were below 200 nm in size, with a mono dispersed size distribution. The nanogels displayed auto photoquenching qualities in PBS, while their fluorescent intensity strongly correlated with the amount of Pba in the organic solvent. Although Pba was conjugated with PS, the nanogel’s photoactivity, in terms of fluorescent properties, singlet oxygen generation, and photocytotoxicity, was approximately maintained. The results of the study indicate that HA-based nanogels can potentially be applied in photodynamic therapy (PDT). |
