| 초록 |
The increasing needs for accurate and sensitive bioassays has accelerated development of various point-of-care applications. To fulfill the such demands, Fe3O4-Pt/core-shell nanoparticle (MPt/CS NPs) were synthesized and used as nanozyme for bioassay. Fe3O4 was widely studied for its own catalytic activity superior to that of natural enzyme and its own magnetic property. Incorporating Pt to the outer layer of Fe3O4 improve the catalytic activity while constructing the heterogeneous nanostructures. The synthesized MPt/CS NPs were applied into Lateral flow immunoassay (LFIA) strips which is the one of the widely used point-of-care bioassay devices. The improved catalytic activity and the magnetic property of MPt/CS NPs increased the sensitivity more than 100 times of LFIA compared to the sensitivity of conventional LFIA based on Au nanoparticles. |
