| 학회 |
한국화학공학회 |
| 학술대회 |
2011년 가을 (10/26 ~ 10/28, 송도컨벤시아) |
| 권호 |
17권 2호, p.1520 |
| 발표분야 |
생물화공 |
| 제목 |
Production of Polylactic Acid and its Copolymers by metabolically engineered Escherichia coli |
| 초록 |
Polylactic acid (PLA) is a promising biomass-derived polymer, but is currently synthesized by a two-step process: fermentative production of lactic acid followed by chemical polymerization. Here we report production of PLA homopolymer and its copolymer, poly(3-hydroxybutyrate-co-lactate), by direct fermentation of metabolically engineered E. coli. In this study, the metabolic pathways of E. coli were further engineered based on in silico genome-scale metabolic flux analysis. Using this engineered strain, PLA homopolymer and P(3HB-co-LA) copolymers containing up to 70 mol% lactate could be produced up to 11 wt% and 46 wt% from glucose, respectively. [This work was supported by the Korean Systems Biology Research Project (20110002149) of the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea. Further support by the World Class University Program (R32-2008-000-10142-0) through the National Research Foundation of Korea funded by the MEST is appreciated.] |
| 저자 |
박혜민1, 정유경1, 김태용1, 박시재2, 이상엽1
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| 소속 |
1한국과학기술원, 2한국화학(연) |
| 키워드 |
Polylactic Acid; Escherichia coli; Metaolic engineering
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| E-Mail |
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| 원문파일 |
초록 보기 |
