| 초록 |
Gelatin methacrylate (GelMA) hydrogels have been widely used in various biomedical applications due to their physical characteristics and suitable biological properties. However its inherent weak mechanical properties have limited its applications. To overcome these drawbacks, the addition of biopolymer to GelMA could expand its potential applications by improving the mechanical properties and the fast degradability of pristine GelMA hydrogels. Silk fibroin (SF) is an attractive materials due to excellent mechanical property and biodegradability. To induce the SF crystallization, non-solvents were used as β-sheet inducing agent in the post-processing of SF based hydrogel. In this study, the GelMA/SF blended solutions were photo-crosslinked using UV light and a post treatment with non-solvents. Thereafter, effect of the non-solvent type and SF concentration on hydrogel properties were investigated by morphology, secondary structure, compressive modulus, and biodegradability. |
