| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Synthesis of polyethers with pendant primay, seconday, and tertiary amino groups for efficient non-viral vehicle |
| 초록 |
Non-viral gene carriers have received increased attention due to the potential infectious issues in viral vectors. In that context, cationic polymers are particularly interesting owing to their high stability and low immunological responses; however, their intrinsic cytotoxicity should be carefully considered in order to further advance their utility in the biological and biomedical settings. In this study, we designed and synthesized a series of polyethers with various types of pendent amine groups for effective gene delivery while balancing between the gene transfection efficiency and cytotoxicity. The polyethers are synthesized via anionic ring-opening polymerization of functional epoxide monomer such as allyl glycidyl ether followed by the post-polymerization modification with thiol-ene chemistry. The polyether backbone was exploited not only to stabilize the polymer/DNA polyplexes, but also to reduce the cellular toxicities by controlling the types of amines. |
| 저자 |
홍영주, 김병수
|
| 소속 |
연세대 |
| 키워드 |
Anionic ring-opening polymerization; Polyethers; Gene delivery; Polyamines
|
| E-Mail |
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