| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Poly(ethylene glycol) and Poly(L-lactide) Block Copolymers Prepared in the Presence of a Non-metalic monomer activator |
| 초록 |
In this article, we describe the synthesis of poly(ethylene glycol) and poly(L-lactide) block copolymers via ring opening polymerization (ROP) of L-lactide (LA) monomers initiated at the hydroxyl end group of PEG using trifluoromethanesulfonic acid (CF3SO3H) as a monomer activator. The PLLAs obtained had molecular weights close to the theoretical values calculated from the LA:PEG molar ratios, and no side-reactions were observed. A 1H-NMR spectroscopic study showed that the LA carbonyl carbon signal exhibited a change in chemical shift to lower field, caused by electron delocalization of the carbonyl carbon by CF3SO3H. We successfully prepared PEG and PLLA block copolymers using activated monomer mechanism. We believe the results of the present study provide new options in the preparation of biomaterials for biomedical applications. Acknowledgements This work was supported by the Korea Science and Engineering Foundation (KOSEF) pioneer grant (M10711060001-08M1106-00110). |
| 저자 |
이상효1, 오재민2, 손진수1, 김재일3, 권두연3, 이봉3, 김재호1, 강길선2, 김문석1
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| 소속 |
1아주대, 2전북대, 3부경대 |
| 키워드 |
Poly(ethyleneglycol); poly(L-lactide); block copolymer; ring-opening polymerization; trifluoromethanesulfonic acid; activated monomer mechanism.
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| E-Mail |
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