| 학회 |
한국화학공학회 |
| 학술대회 |
2010년 가을 (10/21 ~ 10/22, 대전컨벤션센터) |
| 권호 |
16권 2호, p.1556 |
| 발표분야 |
생물화공 |
| 제목 |
Analysis of the Genome-Scale Metabolic Model of Pichia pastoris |
| 초록 |
Here we present the analysis of the genome-scale metabolic model of the yeast Pichia pastoris, an attractive host for heterologous protein production and capable of producing proteins of therapeutic value. Using the genome-scale metabolic model, characteristics and capacity towards the production of two proteins, human serum albumin (HSA) and human superoxide dismutase (hSOD), were analyzed and metabolic engineering targets were suggested to improve their production. Using genome-scale metabolic model, potential phenotypes can be screen in a high-throughput manner, accelerating the development of strategies for engineering improved strains. [This work was supported by the Korean Systems Biology Research Project (20100002164) of the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea, by the Austrian Science Fund (FWF), project I37-B03, and the Austrian Research Promotion Agency (program FHplus).] |
| 저자 |
박종명1, 손승범1, Alexandra B. Graf2, 김태용1, Brigitte Gasser2, Michael Maurer3, Pau Ferrer4, Diethard Mattanovich2, 이상엽1
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| 소속 |
1한국과학기술원, 2Univ. of Natural Resources and Applied Life Sciences, 3Univ. of Applied Sciences FH-Campus Wien, 4Universitat Autnoma de Barcelona |
| 키워드 |
Pichia pastoris; Genome-Scale Metabolic Model
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| E-Mail |
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| 원문파일 |
초록 보기 |
