| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Measurement of biomarkers using optical properties of inverse opal hydrogels |
| 초록 |
Inverse opal hydrogels (IOHs) has regularly arranged opal-shape void spaces. The porous structure enhances permeability and deformability of the hydrogels. IOH also has photonic property based on the size of the pores and their arrangement. External stimulus can lead volumetric change of pores and diffraction wavelengths shift. With this feature, IOHs are widely studied for target responsive sensors we fabricated high quality biomarker responsive IOHs film by templating photo-polymerization of hydrogel monomers on a three-dimensional (3D) silica nanoparticles (SNPs) colloidal array. To summarize the results, we monitored the diffraction peak shift with controlling the pH and glucose concentration. The IOHs film responded to biomarkers through volume change with increased donnan potential through the hydrogels. With the protein detection we introduced FRET dye modified antibody pair to the IOHs and confirmed the binding of antigen to antibodies which are conjugated to IOH backbones. |
| 저자 |
이효, 신무광, 함승주
|
| 소속 |
연세대 |
| 키워드 |
photinic crystal; hydrogels; biosensor
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| E-Mail |
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