| 초록 |
A variety of drug delivery systems have been investigated for high therapeutic efficacy via easy administration. Among them, transdermal delivery is presented as an attractive alternative to needle-based drug delivery because of patient preferences. Needle-free topical delivery without involving physical damage to the natural skin barrier is still sought after as it can further reduce needle-induced anxiety and is simple to administer. However, this long-standing goal has been elusive since the intact skin is impermeable to most macromolecules. Also, the depth of light penetration in skin in photomedicine is a serious constraint on clinical applications. Here, we show an efficient, noninvasive transdermal delivery using Hyaluronate (HA) derivatives as carrier for not only small molecules, but most macromolecules such as nucleotide, protein and nanoparticles. We will introduce various transdermal nanomedicine researches using HA for biomedical applications. |
