| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of additives on controlled sirolimus release for drug-eluting stents |
| 초록 |
Drug-eluting stents (DES) have been widely used in order to prevent restenosis after stent implantation. Sirolimus (SRL), used to DES, is known to inhibit the proliferation of smooth muscle cell. However, hypersensitivity caused by nondegradable polymer and burst release of SRL from polymer layer were pointed out as disadvantages. In this study, it was hypothesized that SRL release from biodegradable poly(D,L-lactide) (PDLLA) would be controlled by various additives with hydrophilic or hydrophobic property. PDLLA solution with SRL and additive was coated onto the helical stent-like spring by ultrasonic spray method. It was characterized by ATR-FTIR, SEM, DSC, and HPLC. |
| 저자 |
박현진1, 최지연1, 강종희1, 정윤기1, 김익환2, 한동근1
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| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
drug-eluting stent; biodegradable polymers; additives; sirolimus; controlled release
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| E-Mail |
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