| 학회 | 한국화학공학회 |
| 학술대회 | 2008년 봄 (04/23 ~ 04/25, 제주ICC) |
| 권호 | 14권 1호, p.253 |
| 발표분야 | 공정시스템 |
| 제목 | A Computational Framework to Guide the Novel Biochemical Synthetic Pathways |
| 초록 | Currently, the bio-based product is spotlighted as the future-promising resource. There have been several systematical attempts to produce bio-based products from microorganisms. Compared to the previous studies, our framework is more suitable to the synthesis of a metabolite which is not presently produced from any microorganism. Through our framework, several desired attributes for synthesis of novel compounds have been achieved, such as consideration of whole metabolic network, synthesis design based on a target chemical, and applicable candidates for the real experimentation. We are expecting to be able to provide experimentally feasible candidates of biochemical synthesis so that our framework can contribute to production of high value added chemicals from microorganisms. Acknowledgement This work was supported by the Korean Systems Biology Research Program of the Ministry of Science and Technology and by the BK21 project. Further supports from LG Chemicals Chair Professorship, IBM-SUR program, and Center for Ultramicrochemical Process Systems Sponsored by KOSEF are greatly appreciated. |
| 저자 | 조아연, 윤홍석, 이상엽, 박선원 |
| 소속 | 한국과학기술원 |
| 키워드 | metabolite synthesis; systems biology |
| 원문파일 | 초록 보기 |
