| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.83 |
| 발표분야 | 신규고분자 합성 |
| 제목 | Synthesis of Poly(ethyleneglycol-b-ε-caprolactone) Diblock Copolymers and Their Biomedical Application |
| 초록 | Recent development of living ring-opening polymerization of lactones gave a variety of biomaterials with controlled molecular weights. One of the most powerful methods to control ring-opening polymerization is activated monomer cationic polymerization, which can suppress unfavorable reactions such as back-biting and disproportionation. Here we describe the living ring-opening polymerization via activated monomer mechanism to design MPEG-PCL diblock copolymers with desired molecular weights. The polymerization of ε-CL by terminal alcohol of MPEG as an initiator was performed to synthesize MPEG-PCL diblock copolymers in the presence of HCl·Et2O in CH2Cl2 at 25 oC for 24 h. Figure 1 shows the dependence of molecular weight of poly(ε-CL) on the feed ratio of ε-CL for MPEG in the ring-opening polymerization. The molecular weight of poly(ε-CL), calculated by 1H NMR and measured by GPC, increased almost linearly with increasing the feed ratio of ε-CL to MPEG. We confirmed that ring-opening polymerization of ε-CL was proceeded by no termination or chain transfer via living fashion. The obtained diblock copolymers showed comparable good solubility in the aqueous. The polymer solutions exhibited the sol-gel transition according to the temperature change as shown in Figure 2. In addition, these diblock copolymer aqueous solutions formed a gel at body temperature. We confirmed that these MPEG-PCL diblock copolymers have possibility for the biomedical utilization as drug delivery carrier via in situ gel formation. Acknowledge: This work was supported by Sol-Gel Innovation Project of Korea (MOCIE, 10006921). |
| 저자 | 김문석1, 서광수2, 강길선2, 조선행1, 이해방1 |
| 소속 | 1한국화학(연), 2전북대 |
| 키워드 | Diblock Copolymers; MPEG-PCL; Drug Carrier; Gel-Sol |
