화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2006년 가을 (10/27 ~ 10/28, 고려대학교)
권호 12권 2호, p.1802
발표분야 생물화공
제목 pH-responsive behaviors of histidine-conjugated poly(amino acid) nanoparticles
초록 pH-responsive self-assembled nanoparticles of cationic graft copolymers based on histidine-conjugated poly(amino acid) derivatives in an aqueous solution was studied.
Synthesized cationic copolymers formed self-assembled nanoparticles in an aqueous solution. pH-responsive behavior and physicochemical properties of nanoparticles in aqueous solution were extensively studied by light scattering, zeta potential, UV, pH-meter and TEM measurements.
Because histidine moieties contain imidazole and α-amino group, whose pKa values are 6.04 and 9.33, it is expected that these self-assembled nanoparticles of cationic graft copolymers based on histidine-conjugated poly(amino acid) derivatives have a effective endosomolytic property and could escape endosome to deliver drug to the nucleus.
저자 강윤정, 정재현, 김종득
소속 한국과학기술원
키워드 pH-responsive; histidine; poly(amino acid)
E-Mail jdkim@kaist.ac.kr
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