화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2004년 가을 (10/08 ~ 10/09, 경북대학교)
권호 29권 2호, p.687
발표분야 의료용 고분자 부문위원회
제목 Triblock copolymer of PEI-Pluronic-PEI as a new gene carrier system.
초록 For efficient gene delivery into cells, a new formulation method based on using polyethylenimine(PEI)-pluronic F127-polyethylenimine(PEI) micelles is presented in this study. PEI-Pluronic-PEI micelles revealed a little increase in critical micellization concentration (CMC) as compared with unmodified Pluronic micelles. The PEI-Pluronic-PEI micelles were characterized in terms of their effective diameter and surface zeta-potential value under various formulations. It was confirmed that when made micellar complexes with PEI-Pluronic-PEI / DNA, the condensed DNA was effectively protected from the nuclease attack. PEI-Pluronic-PEI / DNA micellar complexes exhibited higher transfection efficiency compared to the control PEI / DNA complexes.
저자 조경철, 최승호, 박태관
소속 한국과학기술원
키워드 pluronic F127; miclle
E-Mail tgpark@kaist.ac.kr