| 학회 |
한국화학공학회 |
| 학술대회 |
2014년 봄 (04/23 ~ 04/25, 창원컨벤션센터) |
| 권호 |
20권 1호, p.430 |
| 발표분야 |
생물화공 |
| 제목 |
Adeno-associated viral gene delivery system for efficient human neural stem cell infection by bioinspiredcatecholamines |
| 초록 |
The development of gene delivery systems is a critical issue for the advancement of therapeutic techniques in the fields of gene therapy and tissue engineering. Substrate mediated gene delivery system is utilized to enhance gene delivery efficiency by localization of bioactive materials on the substrates. It promotes retained gene transfer effectively and induces enhanced gene delivery efficiency. In this study, we employed catecholamine polymers, poly(norepinephrine)(pNE) and poly(dopamine)(pDA) for immobilizing AAV vectors on solid surfaces. The catechol group of pNE or pDA is mimicked of adhesive functional groups from marine foot muscle proteins, since it is a capable of surface modification with sticky property. The adeno-associated virus (AAV) is considered promising as a therapeutic vector because it is relatively safe and has the ability to target genes in stem cells. Therefore the development of surface mediated AAV vector delivery system by catecholamine materials has a great potential to apply and formation newly interface science including gene therapy engineering. |
| 저자 |
김은미1, 이슬기림1, 홍선기2, 진규형1, 김민희1, 박국인1, 이해신2, 장재형1
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| 소속 |
1연세대, 2KAIST |
| 키워드 |
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| E-Mail |
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| 원문파일 |
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