| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 | 22권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Release Kinetics of Alendronate from Chitosan Microsphere |
| 초록 | Chitosan (CHN) is widely used as biomaterials due to its biocompatibility and biodegradability. In particular, CHN molecule carries highly positive charges different from most of other biomolecules. CHN can be used as a drug carrier in drug delivery system. In this study, we prepared alendronate-loaded CHN microspheres and evaluated the efficacy of drug loading and release pattern. The physicochemical properties of drug-loaded CHN microspheres including size, surface charge, surface morphology were thoroughly examined using zeta potential, scanning electron microscope. The drug release pattern was evaluated using high performance liquid chromatography. The effects of drug release on the growth and differentiation of osteoblastic cells were characterized via cellular assays. This research was supported by the Ministry of Trade, Industry and Energy(MOTIE), KOREA, through the Education Program for Creative and Industrial Convergence. (Grant Number N0000717). |
| 저자 | xumengcan, 마진쉬엔, 홍재윤, 오지영, 이우걸 |
| 소속 | 단국대 |
| 키워드 | Chitosan; Alendronate; Microsphere |
